Inlet cell transplantation: important factors contributing to optimal pancreatic function

This study investigates four factors which are of utmost importance in contributing to optimal function of pancreatic tissue fragment allo transplants. Those being: viability of donor tissue, optimal weight of pancreatic tissue fragments, method of allograft preparation, and site of implantation. Seven groups of unrelated mongrel dogs underwent total pancreatectomy before being randomly assigned to one of the follo wing experimental groups. Group I (n = 10) anmimales were transplanted with >0.75 g/kg of viable, pancreatic tissue fragments, whereas those in Group II (n = 6) received <0.75 g/kg of nonviable pancreatic pieces. In both groups, the donor pancreases were processed without collagenase, before being injected into the renal subcapsular space. Mean survical among Group I animals was 43 ñ 17 days (M ñ SD), while dogs in Group II survived a mean of 2.6 ñ 0.9 days (M ñ SD). Dogs in Group III (n = 5) were injected in the supracapsular peritoneum with >0.75 g/kg of viable, collagenase-frww pancreatic tissue fragments, and mean survical was noted to be 3.1 ñ 1.2 days (M ñ SD). Recipients in Group IV (n = 5) received >0.75 g/kg of nonviable pancreatic tissue pieces prepared without collagenase in the renal subcapasular space, resulting in a mean survical of 2.8 ñ 0.9 days (M ñ SD). Group V (n = 6) animals survived a mean of 20 ñ 18 days (M ñ SD) when transplanted with >0.75 g/kg of viable pancreatic tissue fragments prepared with collagenase, in the renal subcapsular space. Animals in Group VI (n = 6) were injected intrasplenically with <0.75 g/kg of nonviable pancreatic pieces prepared without collagenase, and survived a mean of 4.2 ñ 1.2 days (M ñ SD). Viable, intrasplenic allografts of >0.75 g/kg were prepared with collagenase and administered to Group VII (n = 6) animals, who survived a mean of 7.7 ñ 4.6 days (M ñ SD). Animals in groups I-VII were given 2.5 mg/kg/day of azathioprine post-transplant, until death...

Hypertensión in cadaver kidney transplantation

Este estudio analiza la evolución de la hipertensión arterial en pacientes con trasplante renal. Todos los pacientes fueron evaluados antes y después del trasplante en cuanto a la presencia de enfermedad hipertensiva y después se siguieron por 18 meses. El sexo, edad, y la raza no estuvieron directamente asociados con el curso de la hipertención arterial del trasplante. Existió, sin embargo, una relación entre la enfermedad nativa renal y los cambios en presión arterial después del trasplante. El grupo de trasplante de riñón con empeoramiento de la hipertensión arterial tuvo número mayor de rechazos, que el grupo que demostró mejoría de la presión arterial. Hasta que punto esta hallazgo es un factor negativo, es difícil poder demostrarlo definitivamente. En general, las causas y mecanismos relacionados con la hipertensión arterial después del trasplante fueron complejos y multifactoriales